Astrocytes and Oligodendrocytes Express Different STOP Protein Isoforms

MAURICIO R. GALIANO; BOSC C.; SCHWEITZER A.; ANDRIEUX A.; JOB D.; MARTA E. HALLAK

WILEY-LISS, DIV JOHN WILEY & SONS INC

Lugar: New York; Año: 2004 p. 329 - 329

p style="TEXT-ALIGN: justify; LINE-HEIGHT: normal; MARGIN: 0in 0in 0pt; mso-layout-grid-align: none" class="MsoNormal">Many cell types contain subpopulations of microtubules that resist depolymerizing conditions, such as exposure to cold or to the drug nocodazole. This stabilization is due mainly to polymer association with STOP proteins. In mouse, neurons express two major variants of these proteins, N-STOP and E-STOP (120 kDa and 79 kDa, respectively), whereas fibroblasts express F-STOP (42 kDa) and two minor variants of 48 and 89 kDa. N- and E-STOP induce microtubule resistance to both cold and nocodazole exposure, whereas F-STOP confers microtubule stability only to the cold. Here, we investigated the expression of STOP proteins in oligodendrocytes and astrocytes in culture. We found that STOP proteins were expressed in precursor cells, in immature and mature oligodendrocytes, and